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Moreover, pretreatment of aged mice with mixed probiotics (VSL#3) mitigated anesthesia/surgery-induced memory impairment by eliminating gut microbiota dysbiosis (Jiang et al., 2019)

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(PubMed) Brace LD

Therefore, researchers should conduct more in-depth and multifaceted studies to confirm that targeting the HUWE1-TfR1 axis is a new strategy for clinical intervention in ALF